Drug interactions
Carbamazepine + Ripretinib
Severity: Major
Carbamazepine and Ripretinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and can lower exposure to ripretinib and its active metabolite. This may reduce antitumor efficacy in patients with gastrointestinal stromal tumors.
What this interaction means in plain words
Carbamazepine and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Ripretinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by carbamazepine increases the metabolic clearance of ripretinib and its active metabolite.
What to do
Avoid combining with strong CYP3A inducers and switch to a non-inducing anticonvulsant if possible. If it cannot be avoided, follow labeling for ripretinib dose adjustment and monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
- Ripretinib + Secobarbital Major
Frequently asked questions
Can I take Carbamazepine with Ripretinib?
MediHelp rates the interaction as major. Carbamazepine and Ripretinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong CYP3A4 inducer and can lower exposure to ripretinib and its active metabolite. This may reduce antitumor efficacy in patients with gastrointestinal stromal tumors.
How serious is the interaction between Carbamazepine and Ripretinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A inducers and switch to a non-inducing anticonvulsant if possible. If it cannot be avoided, follow labeling for ripretinib dose adjustment and monitor tumor response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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