Drug interactions
Efavirenz + Selexipag
Severity: Minor
Efavirenz and Selexipag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selexipag is converted to its active metabolite partly via CYP2C8-linked pathways. Efavirenz is not a clear CYP2C8 inhibitor, so any increase in exposure is uncertain.
What this interaction means in plain words
Efavirenz and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Selexipag belongs to Cardiovascular.
Why it happens
Possible weak CYP2C8 inhibition by efavirenz; not clearly established.
What to do
Monitor for prostacyclin-related adverse effects such as headache, diarrhea and jaw pain, and reduce selexipag frequency if poorly tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Selexipag
- Gemfibrozil + Selexipag Contraindicated
- Abiraterone + Selexipag Moderate
- Apalutamide + Selexipag Moderate
- Carbamazepine + Selexipag Moderate
- Clopidogrel + Selexipag Moderate
- Cyclosporin + Selexipag Moderate
Frequently asked questions
Can I take Efavirenz with Selexipag?
MediHelp rates the interaction as minor. Efavirenz and Selexipag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selexipag is converted to its active metabolite partly via CYP2C8-linked pathways. Efavirenz is not a clear CYP2C8 inhibitor, so any increase in exposure is uncertain.
How serious is the interaction between Efavirenz and Selexipag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for prostacyclin-related adverse effects such as headache, diarrhea and jaw pain, and reduce selexipag frequency if poorly tolerated.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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