Drug interactions
Efavirenz + Tivozanib
Severity: Moderate
Efavirenz and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower tivozanib concentrations and reduce its efficacy in renal cell carcinoma. Strong CYP3A4 inducers are advised against with tivozanib.
What this interaction means in plain words
Efavirenz and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Tivozanib belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of tivozanib.
What to do
Prefer a non-inducing antiretroviral regimen. If coadministered, monitor tumor response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
Frequently asked questions
Can I take Efavirenz with Tivozanib?
MediHelp rates the interaction as moderate. Efavirenz and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower tivozanib concentrations and reduce its efficacy in renal cell carcinoma. Strong CYP3A4 inducers are advised against with tivozanib.
How serious is the interaction between Efavirenz and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiretroviral regimen. If coadministered, monitor tumor response closely.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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