Drug interactions
Secobarbital + Tivozanib
Severity: Major
Secobarbital and Tivozanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and reduce tivozanib exposure. Lower exposure may lessen efficacy in renal cell carcinoma.
What this interaction means in plain words
Secobarbital and Tivozanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Secobarbital belongs to Central Nervous System; Tivozanib belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases tivozanib clearance.
What to do
Avoid strong CYP3A4 inducers and choose a different sedative. Monitor for loss of response if it is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Apalutamide + Tivozanib Moderate
- Bosentan + Tivozanib Moderate
- Efavirenz + Tivozanib Moderate
Frequently asked questions
Can I take Secobarbital with Tivozanib?
MediHelp rates the interaction as major. Secobarbital and Tivozanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may induce CYP3A4 and reduce tivozanib exposure. Lower exposure may lessen efficacy in renal cell carcinoma.
How serious is the interaction between Secobarbital and Tivozanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers and choose a different sedative. Monitor for loss of response if it is unavoidable.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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