Drug interactions
Apalutamide + Tivozanib
Severity: Moderate
Apalutamide and Tivozanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower tivozanib exposure because tivozanib is a CYP3A4 substrate. Reduced exposure may compromise anticancer efficacy.
What this interaction means in plain words
Apalutamide and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Tivozanib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, accelerating tivozanib metabolism.
What to do
Monitor for reduced tumor response and consider an alternative to apalutamide if possible. Avoid combining with other strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Tivozanib
- Amobarbital + Tivozanib Major
- Carbamazepine + Tivozanib Major
- Phenytoin + Tivozanib Major
- Secobarbital + Tivozanib Major
- Bosentan + Tivozanib Moderate
- Efavirenz + Tivozanib Moderate
Frequently asked questions
Can I take Apalutamide with Tivozanib?
MediHelp rates the interaction as moderate. Apalutamide and Tivozanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower tivozanib exposure because tivozanib is a CYP3A4 substrate. Reduced exposure may compromise anticancer efficacy.
How serious is the interaction between Apalutamide and Tivozanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and consider an alternative to apalutamide if possible. Avoid combining with other strong inducers.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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