Drug interactions
Efavirenz + Umeclidinium-vilanterol
Severity: Minor
Efavirenz and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and may lower vilanterol exposure, although the effect on inhaled vilanterol is probably small. Efavirenz also has a known QT-prolonging potential that could add to beta-agonist cardiac effects. Overall clinical impact is generally limited.
What this interaction means in plain words
Efavirenz and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 induction by efavirenz may reduce vilanterol levels, with possible additive effects on QT.
What to do
Monitor for reduced bronchodilator response. Check ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Efavirenz and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz induces CYP3A4 and may lower vilanterol exposure, although the effect on inhaled vilanterol is probably small. Efavirenz also has a known QT-prolonging potential that could add to beta-agonist cardiac effects. Overall clinical impact is generally limited.
How serious is the interaction between Efavirenz and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bronchodilator response. Check ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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