Drug interactions
Efavirenz + Vinblastine
Severity: Moderate
Efavirenz and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may reduce vinblastine exposure by inducing its metabolism, potentially lessening antineoplastic effect. The magnitude is uncertain and is likely modest.
What this interaction means in plain words
Efavirenz and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vinblastine belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, which is the main metabolic pathway of vinblastine.
What to do
Monitor tumor response and toxicity closely. Where an alternative antiretroviral without CYP3A4 induction is feasible, consider it during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Efavirenz with Vinblastine?
MediHelp rates the interaction as moderate. Efavirenz and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may reduce vinblastine exposure by inducing its metabolism, potentially lessening antineoplastic effect. The magnitude is uncertain and is likely modest.
How serious is the interaction between Efavirenz and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity closely. Where an alternative antiretroviral without CYP3A4 induction is feasible, consider it during chemotherapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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