Drug interactions
Efavirenz + Vonoprazan
Severity: Moderate
Efavirenz and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower vonoprazan exposure and reduce acid suppression. Reduced effect could compromise treatment of erosive esophagitis or H. pylori regimens.
What this interaction means in plain words
Efavirenz and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Efavirenz induces CYP3A4, which contributes to vonoprazan metabolism.
What to do
Monitor symptom control and consider an alternative acid suppressant if response is inadequate. Check for compatibility with the antiretroviral regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Efavirenz with Vonoprazan?
MediHelp rates the interaction as moderate. Efavirenz and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower vonoprazan exposure and reduce acid suppression. Reduced effect could compromise treatment of erosive esophagitis or H. pylori regimens.
How serious is the interaction between Efavirenz and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider an alternative acid suppressant if response is inadequate. Check for compatibility with the antiretroviral regimen.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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