Drug interactions
Efgartigimod alfa + Ustekinumab
Severity: Moderate
Efgartigimod alfa and Ustekinumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which recycles IgG and extends its half-life. Ustekinumab is an IgG1 antibody, so its clearance may rise and exposure and effect may fall.
What this interaction means in plain words
Efgartigimod alfa and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
FcRn blockade increases catabolism of IgG-based drugs such as ustekinumab.
What to do
Monitor for loss of ustekinumab efficacy while on efgartigimod. If disease control worsens, consider alternatives or dose timing adjustments.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Bevacizumab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Efgartigimod alfa with Ustekinumab?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Ustekinumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which recycles IgG and extends its half-life. Ustekinumab is an IgG1 antibody, so its clearance may rise and exposure and effect may fall.
How serious is the interaction between Efgartigimod alfa and Ustekinumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of ustekinumab efficacy while on efgartigimod. If disease control worsens, consider alternatives or dose timing adjustments.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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