Drug interactions
Efgartigimod / hyaluronidase sc + Hepatitis b immune globulin
Severity: Moderate
Efgartigimod / hyaluronidase sc and Hepatitis b immune globulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and speeds IgG clearance, so passively administered immune globulin may be cleared faster. This could shorten the protective antibody levels provided by HBIG.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Hepatitis b immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade reduces IgG recycling and increases clearance of IgG-based products.
What to do
Monitor hepatitis B surface antibody titers in patients relying on HBIG, such as after liver transplant, and adjust HBIG dosing accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis b immune globulin
- Efgartigimod alfa + Hepatitis b immune globulin Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine live Moderate
- Hepatitis b immune globulin + Measles mumps rubella and varicella vaccine live Moderate
- Hepatitis b immune globulin + Measles vaccine Moderate
- Hepatitis b immune globulin + Rozanolixizumab Moderate
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Hepatitis b immune globulin?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Hepatitis b immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and speeds IgG clearance, so passively administered immune globulin may be cleared faster. This could shorten the protective antibody levels provided by HBIG.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Hepatitis b immune globulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hepatitis B surface antibody titers in patients relying on HBIG, such as after liver transplant, and adjust HBIG dosing accordingly.
What other medicines interact with Hepatitis b immune globulin?
MediHelp also lists interactions of Hepatitis b immune globulin with, for example, Efgartigimod alfa, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Hepatitis b immune globulin page.
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