Drug interactions
Hepatitis b immune globulin + Measles mumps and rubella vaccine
Severity: Moderate
Hepatitis b immune globulin and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibodies in hepatitis B immune globulin can neutralise live measles and rubella vaccine viruses, reducing the immune response to the vaccine. This may leave the recipient inadequately protected.
What this interaction means in plain words
Hepatitis b immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis b immune globulin belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
Passively acquired antibodies neutralise replication of live attenuated vaccine viruses.
What to do
Delay MMR vaccination after HBIG according to current immunisation guidance, typically about 3 months. Alternatively, give the vaccine first and avoid immune globulin for at least 2 weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Hepatitis b immune globulin
- Efgartigimod / hyaluronidase sc + Hepatitis b immune globulin Moderate
- Efgartigimod alfa + Hepatitis b immune globulin Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine live Moderate
- Hepatitis b immune globulin + Measles mumps rubella and varicella vaccine live Moderate
- Hepatitis b immune globulin + Measles vaccine Moderate
- Hepatitis b immune globulin + Rozanolixizumab Moderate
Frequently asked questions
Can I take Hepatitis b immune globulin with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Hepatitis b immune globulin and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibodies in hepatitis B immune globulin can neutralise live measles and rubella vaccine viruses, reducing the immune response to the vaccine. This may leave the recipient inadequately protected.
How serious is the interaction between Hepatitis b immune globulin and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay MMR vaccination after HBIG according to current immunisation guidance, typically about 3 months. Alternatively, give the vaccine first and avoid immune globulin for at least 2 weeks.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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