Drug interactions
Hepatitis b immune globulin + Rozanolixizumab
Severity: Moderate
Hepatitis b immune globulin and Rozanolixizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG and prolongs its half-life. Hepatitis B immune globulin is an IgG product, so its serum levels may fall faster and passive protection may be shorter than expected.
What this interaction means in plain words
Hepatitis b immune globulin and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hepatitis b immune globulin belongs to Miscellaneous; Rozanolixizumab belongs to Miscellaneous.
Why it happens
Blockade of the neonatal Fc receptor by rozanolixizumab increases catabolism of exogenous IgG, lowering exposure to the immune globulin.
What to do
When HBIG is given for post-exposure or perinatal prophylaxis, check anti-HBs titers and repeat dosing if levels are inadequate. Follow the hepatitis B vaccination schedule and consider timing HBIG away from rozanolixizumab infusions where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis b immune globulin
- Efgartigimod / hyaluronidase sc + Hepatitis b immune globulin Moderate
- Efgartigimod alfa + Hepatitis b immune globulin Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine live Moderate
- Hepatitis b immune globulin + Measles mumps rubella and varicella vaccine live Moderate
- Hepatitis b immune globulin + Measles vaccine Moderate
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Hepatitis b immune globulin with Rozanolixizumab?
MediHelp rates the interaction as moderate. Hepatitis b immune globulin and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which normally recycles IgG and prolongs its half-life. Hepatitis B immune globulin is an IgG product, so its serum levels may fall faster and passive protection may be shorter than expected.
How serious is the interaction between Hepatitis b immune globulin and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When HBIG is given for post-exposure or perinatal prophylaxis, check anti-HBs titers and repeat dosing if levels are inadequate. Follow the hepatitis B vaccination schedule and consider timing HBIG away from rozanolixizumab infusions where feasible.
What other medicines interact with Hepatitis b immune globulin?
MediHelp also lists interactions of Hepatitis b immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Measles mumps and rubella vaccine. The full list is on the Hepatitis b immune globulin page.
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