Drug interactions
Hepatitis b immune globulin + Measles mumps rubella and varicella vaccine live
Severity: Moderate
Hepatitis b immune globulin and Measles mumps rubella and varicella vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies in immune globulin products can neutralize live MMRV vaccine viruses and reduce vaccine take. HBIG contains lower measles-specific antibody than other products, but the interference is possible.
What this interaction means in plain words
Hepatitis b immune globulin and Measles mumps rubella and varicella vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize the live attenuated viruses and blunt the vaccine immune response.
What to do
Follow national immunization guidance on intervals; HBIG typically requires a short delay of live MMRV vaccine, and revaccinate if given too soon.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hepatitis b immune globulin
- Efgartigimod / hyaluronidase sc + Hepatitis b immune globulin Moderate
- Efgartigimod alfa + Hepatitis b immune globulin Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine Moderate
- Hepatitis b immune globulin + Measles mumps and rubella vaccine live Moderate
- Hepatitis b immune globulin + Measles vaccine Moderate
- Hepatitis b immune globulin + Rozanolixizumab Moderate
Frequently asked questions
Can I take Hepatitis b immune globulin with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as moderate. Hepatitis b immune globulin and Measles mumps rubella and varicella vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passive antibodies in immune globulin products can neutralize live MMRV vaccine viruses and reduce vaccine take. HBIG contains lower measles-specific antibody than other products, but the interference is possible.
How serious is the interaction between Hepatitis b immune globulin and Measles mumps rubella and varicella vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow national immunization guidance on intervals; HBIG typically requires a short delay of live MMRV vaccine, and revaccinate if given too soon.
What other medicines interact with Hepatitis b immune globulin?
MediHelp also lists interactions of Hepatitis b immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Measles mumps and rubella vaccine. The full list is on the Hepatitis b immune globulin page.
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