Drug interactions
Efgartigimod / hyaluronidase sc + Rabies immune globulin
Severity: Moderate
Efgartigimod / hyaluronidase sc and Rabies immune globulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and lowers circulating IgG. Rabies immune globulin is IgG, so its levels may fall faster and passive protection after exposure may be reduced.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Rabies immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Neonatal Fc receptor blockade increases catabolism of exogenous IgG.
What to do
Give full-dose RIG with wound infiltration and complete the rabies vaccine series promptly. Consider rabies virus neutralizing antibody titers after the series.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabies immune globulin
- Efgartigimod alfa + Rabies immune globulin Moderate
- Rabies immune globulin + Rabies vaccine Moderate
- Rabies immune globulin + Rabies vaccine chick embryo cell derived Moderate
- Rabies immune globulin + Rozanolixizumab Moderate
- Measles mumps and rubella vaccine live + Rabies immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Rabies immune globulin Minor
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Rabies immune globulin?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Rabies immune globulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and lowers circulating IgG. Rabies immune globulin is IgG, so its levels may fall faster and passive protection after exposure may be reduced.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Rabies immune globulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give full-dose RIG with wound infiltration and complete the rabies vaccine series promptly. Consider rabies virus neutralizing antibody titers after the series.
What other medicines interact with Rabies immune globulin?
MediHelp also lists interactions of Rabies immune globulin with, for example, Efgartigimod alfa, Rabies vaccine, Rabies vaccine chick embryo cell derived. The full list is on the Rabies immune globulin page.
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