Drug interactions
Rabies immune globulin + Rozanolixizumab
Severity: Moderate
Rabies immune globulin and Rozanolixizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG. Rabies immune globulin is IgG, so its levels may fall faster and passive protection after exposure may be reduced.
What this interaction means in plain words
Rabies immune globulin and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rabies immune globulin belongs to Miscellaneous; Rozanolixizumab belongs to Miscellaneous.
Why it happens
Neonatal Fc receptor blockade increases catabolism of exogenous IgG.
What to do
Give full-dose RIG with wound infiltration and complete the rabies vaccine series promptly. Consider rabies virus neutralizing antibody titers after the series.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabies immune globulin
- Efgartigimod / hyaluronidase sc + Rabies immune globulin Moderate
- Efgartigimod alfa + Rabies immune globulin Moderate
- Rabies immune globulin + Rabies vaccine Moderate
- Rabies immune globulin + Rabies vaccine chick embryo cell derived Moderate
- Measles mumps and rubella vaccine live + Rabies immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Rabies immune globulin Minor
Other interactions of Rozanolixizumab
- Rozanolixizumab + Upadacitinib Major
- Abatacept + Rozanolixizumab Moderate
- Adalimumab + Rozanolixizumab Moderate
- Ado-trastuzumab + Rozanolixizumab Moderate
- Basiliximab + Rozanolixizumab Moderate
- Bevacizumab + Rozanolixizumab Moderate
Frequently asked questions
Can I take Rabies immune globulin with Rozanolixizumab?
MediHelp rates the interaction as moderate. Rabies immune globulin and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor and lowers circulating IgG. Rabies immune globulin is IgG, so its levels may fall faster and passive protection after exposure may be reduced.
How serious is the interaction between Rabies immune globulin and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give full-dose RIG with wound infiltration and complete the rabies vaccine series promptly. Consider rabies virus neutralizing antibody titers after the series.
What other medicines interact with Rabies immune globulin?
MediHelp also lists interactions of Rabies immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rabies vaccine. The full list is on the Rabies immune globulin page.
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