Drug interactions
Rabies immune globulin + Rabies vaccine chick embryo cell derived
Severity: Moderate
Rabies immune globulin and Rabies vaccine chick embryo cell derived: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabies immune globulin given with or after the vaccine can suppress the active antibody response to the vaccine. Both are still used together for post-exposure prophylaxis because RIG gives immediate passive protection.
What this interaction means in plain words
Rabies immune globulin and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passive antibody binds vaccine antigen and dampens the active humoral immune response.
What to do
Give RIG only once, with the first vaccine dose, infiltrating the wound, and do not exceed the labeled RIG dose. Give the vaccine at a different anatomic site and complete the full series.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabies immune globulin
- Efgartigimod / hyaluronidase sc + Rabies immune globulin Moderate
- Efgartigimod alfa + Rabies immune globulin Moderate
- Rabies immune globulin + Rabies vaccine Moderate
- Rabies immune globulin + Rozanolixizumab Moderate
- Measles mumps and rubella vaccine live + Rabies immune globulin Minor
- Measles mumps rubella and varicella vaccine live + Rabies immune globulin Minor
Frequently asked questions
Can I take Rabies immune globulin with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as moderate. Rabies immune globulin and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabies immune globulin given with or after the vaccine can suppress the active antibody response to the vaccine. Both are still used together for post-exposure prophylaxis because RIG gives immediate passive protection.
How serious is the interaction between Rabies immune globulin and Rabies vaccine chick embryo cell derived?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give RIG only once, with the first vaccine dose, infiltrating the wound, and do not exceed the labeled RIG dose. Give the vaccine at a different anatomic site and complete the full series.
What other medicines interact with Rabies immune globulin?
MediHelp also lists interactions of Rabies immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rabies vaccine. The full list is on the Rabies immune globulin page.
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