Drug interactions
Measles mumps rubella and varicella vaccine live + Rabies immune globulin
Severity: Minor
Measles mumps rubella and varicella vaccine live and Rabies immune globulin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies may reduce replication of live MMRV vaccine viruses. Rabies immune globulin contains little antibody to these viruses, so the effect is expected to be small.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Rabies immune globulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical neutralization of live vaccine virus by passively acquired antibody.
What to do
No routine delay is required for rabies immune globulin. Check serology or revaccinate if immunity is in doubt.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabies immune globulin
- Efgartigimod / hyaluronidase sc + Rabies immune globulin Moderate
- Efgartigimod alfa + Rabies immune globulin Moderate
- Rabies immune globulin + Rabies vaccine Moderate
- Rabies immune globulin + Rabies vaccine chick embryo cell derived Moderate
- Rabies immune globulin + Rozanolixizumab Moderate
- Measles mumps and rubella vaccine live + Rabies immune globulin Minor
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Rabies immune globulin?
MediHelp rates the interaction as minor. Measles mumps rubella and varicella vaccine live and Rabies immune globulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Passive antibodies may reduce replication of live MMRV vaccine viruses. Rabies immune globulin contains little antibody to these viruses, so the effect is expected to be small.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Rabies immune globulin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine delay is required for rabies immune globulin. Check serology or revaccinate if immunity is in doubt.
What other medicines interact with Rabies immune globulin?
MediHelp also lists interactions of Rabies immune globulin with, for example, Efgartigimod / hyaluronidase sc, Efgartigimod alfa, Rabies vaccine. The full list is on the Rabies immune globulin page.
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