Drug interactions
Efgartigimod / hyaluronidase sc + Sarilumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks FcRn and lowers circulating IgG. Sarilumab, an IgG1 antibody, may have reduced exposure and efficacy.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade increases the catabolism of IgG-based drugs such as sarilumab.
What to do
Monitor for reduced sarilumab response. If sarilumab is essential long term, consider alternative therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarilumab
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Sarilumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks FcRn and lowers circulating IgG. Sarilumab, an IgG1 antibody, may have reduced exposure and efficacy.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sarilumab response. If sarilumab is essential long term, consider alternative therapy.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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