Drug interactions
Efgartigimod / hyaluronidase sc + Upadacitinib
Severity: Moderate
Efgartigimod / hyaluronidase sc and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Subcutaneous efgartigimod reduces IgG and may increase infection susceptibility. With upadacitinib the immunosuppressive effect may be additive, though evidence is limited.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immune suppression from FcRn blockade reducing IgG and JAK inhibition.
What to do
Monitor for infection during combined use, and reassess the need for both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Upadacitinib?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Subcutaneous efgartigimod reduces IgG and may increase infection susceptibility. With upadacitinib the immunosuppressive effect may be additive, though evidence is limited.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection during combined use, and reassess the need for both agents.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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