Drug interactions
Elacestrant + Erythromycin
Severity: Major
Elacestrant and Erythromycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
What this interaction means in plain words
Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of elacestrant increases its exposure.
What to do
Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Erythromycin?
MediHelp rates the interaction as major. Elacestrant and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin, a moderate CYP3A4 inhibitor, can raise elacestrant concentrations and increase its adverse effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
How serious is the interaction between Elacestrant and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose a non-CYP3A4-inhibiting antibiotic such as azithromycin or doxycycline where appropriate. If unavoidable, monitor for elacestrant adverse effects such as nausea and hepatic enzyme changes.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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