Drug interactions
Elacestrant + Irinotecan
Severity: Moderate
Elacestrant and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits BCRP, which transports irinotecan and SN-38. Exposure may rise, increasing the risk of diarrhoea and neutropenia.
What this interaction means in plain words
Elacestrant and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Irinotecan belongs to Oncology.
Why it happens
BCRP inhibition by elacestrant reduces efflux of SN-38 and irinotecan.
What to do
Monitor blood counts and diarrhoea, and consider reducing the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Irinotecan?
MediHelp rates the interaction as moderate. Elacestrant and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant inhibits BCRP, which transports irinotecan and SN-38. Exposure may rise, increasing the risk of diarrhoea and neutropenia.
How serious is the interaction between Elacestrant and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhoea, and consider reducing the irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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