Drug interactions
Elacestrant + Ketoconazole
Severity: Major
Elacestrant and Ketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole substantially increases elacestrant exposure, which may heighten adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding strong CYP3A4 inhibitors.
What this interaction means in plain words
Elacestrant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP3A4, the main metabolic pathway for elacestrant.
What to do
Avoid concomitant use and select an antifungal without strong CYP3A4 inhibition. If it cannot be avoided, monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Ketoconazole?
MediHelp rates the interaction as major. Elacestrant and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole substantially increases elacestrant exposure, which may heighten adverse effects such as nausea, dyslipidemia and musculoskeletal pain. Labeling advises avoiding strong CYP3A4 inhibitors.
How serious is the interaction between Elacestrant and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an antifungal without strong CYP3A4 inhibition. If it cannot be avoided, monitor for toxicity.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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