Drug interactions
Elbasvir / grazoprevir + Eslicarbazepine
Severity: Major
Elbasvir / grazoprevir and Eslicarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may markedly lower elbasvir and grazoprevir concentrations by CYP3A4 induction. This can lead to hepatitis C treatment failure.
What this interaction means in plain words
Elbasvir / grazoprevir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Eslicarbazepine induces CYP3A4 and may affect transporter-mediated disposition, reducing elbasvir and grazoprevir exposure.
What to do
Avoid the combination; switch to a non-inducing antiseizure drug during hepatitis C therapy. If not possible, consult a hepatology or infectious disease specialist about an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Elbasvir / grazoprevir with Eslicarbazepine?
MediHelp rates the interaction as major. Elbasvir / grazoprevir and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine may markedly lower elbasvir and grazoprevir concentrations by CYP3A4 induction. This can lead to hepatitis C treatment failure.
How serious is the interaction between Elbasvir / grazoprevir and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; switch to a non-inducing antiseizure drug during hepatitis C therapy. If not possible, consult a hepatology or infectious disease specialist about an alternative regimen.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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