Drug interactions
Elbasvir / grazoprevir + Nevirapine
Severity: Contraindicated
Elbasvir / grazoprevir and Nevirapine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may markedly lower elbasvir and grazoprevir concentrations, risking failure of hepatitis C therapy and resistance.
What this interaction means in plain words
Elbasvir / grazoprevir and Nevirapine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nevirapine induces CYP3A4 and may also affect P-glycoprotein, reducing exposure of both agents.
What to do
Do not combine; switch to a non-inducing antiretroviral before starting hepatitis C treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nevirapine
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
- Apalutamide + Nevirapine Major
Frequently asked questions
Can I take Elbasvir / grazoprevir with Nevirapine?
MediHelp rates the interaction as contraindicated. Elbasvir / grazoprevir and Nevirapine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nevirapine may markedly lower elbasvir and grazoprevir concentrations, risking failure of hepatitis C therapy and resistance.
How serious is the interaction between Elbasvir / grazoprevir and Nevirapine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a non-inducing antiretroviral before starting hepatitis C treatment.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Ranolazine, St john's wort, Abemaciclib. The full list is on the Nevirapine page.
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