Drug interactions
Nevirapine + Ranolazine
Severity: Contraindicated
Nevirapine and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce ranolazine concentrations, risking loss of antianginal effect. Labeling contraindicates ranolazine with CYP3A inducers.
What this interaction means in plain words
Nevirapine and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nevirapine belongs to Anti Virals; Ranolazine belongs to Cardiovascular.
Why it happens
Nevirapine induces CYP3A4, increasing ranolazine clearance.
What to do
Avoid the combination. Use an alternative antianginal agent or a non-inducing antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
- Apalutamide + Nevirapine Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Nevirapine with Ranolazine?
MediHelp rates the interaction as contraindicated. Nevirapine and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nevirapine may reduce ranolazine concentrations, risking loss of antianginal effect. Labeling contraindicates ranolazine with CYP3A inducers.
How serious is the interaction between Nevirapine and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an alternative antianginal agent or a non-inducing antiretroviral.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, St john's wort, Abemaciclib. The full list is on the Nevirapine page.
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