Drug interactions
Amobarbital + Nevirapine
Severity: Major
Amobarbital and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and may lower nevirapine concentrations, risking virologic failure and resistance. Nevirapine may also affect barbiturate levels, but the main concern is loss of antiretroviral efficacy.
What this interaction means in plain words
Amobarbital and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Nevirapine belongs to Anti Virals.
Why it happens
Barbiturates induce CYP3A4 and CYP2B6, increasing nevirapine clearance.
What to do
Avoid the combination if possible and use a non-inducing sedative or anticonvulsant. If unavoidable, monitor HIV viral load and consider nevirapine concentrations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Apalutamide + Nevirapine Major
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Nevirapine?
MediHelp rates the interaction as major. Amobarbital and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is an enzyme inducer and may lower nevirapine concentrations, risking virologic failure and resistance. Nevirapine may also affect barbiturate levels, but the main concern is loss of antiretroviral efficacy.
How serious is the interaction between Amobarbital and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-inducing sedative or anticonvulsant. If unavoidable, monitor HIV viral load and consider nevirapine concentrations.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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