Drug interactions
Elbasvir / grazoprevir + Ribociclib
Severity: Moderate
Elbasvir / grazoprevir and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grazoprevir is a CYP3A and OATP1B substrate, and elbasvir is also a CYP3A substrate. Ribociclib may increase their concentrations, raising the possibility of ALT elevation. Ribociclib also has hepatotoxic potential.
What this interaction means in plain words
Elbasvir / grazoprevir and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ribociclib reduces elbasvir and grazoprevir clearance.
What to do
Monitor liver enzymes during co-therapy. Consider timing hepatitis C therapy outside ribociclib treatment where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Ribociclib?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grazoprevir is a CYP3A and OATP1B substrate, and elbasvir is also a CYP3A substrate. Ribociclib may increase their concentrations, raising the possibility of ALT elevation. Ribociclib also has hepatotoxic potential.
How serious is the interaction between Elbasvir / grazoprevir and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during co-therapy. Consider timing hepatitis C therapy outside ribociclib treatment where feasible.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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