Drug interactions
Elbasvir / grazoprevir + Tacrolimus
Severity: Moderate
Elbasvir / grazoprevir and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Coadministration has been associated with higher tacrolimus concentrations. Elevated levels risk nephrotoxicity and neurotoxicity.
What this interaction means in plain words
Elbasvir / grazoprevir and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely inhibition of intestinal CYP3A4 by grazoprevir, though the mechanism is not fully established.
What to do
Monitor tacrolimus whole blood concentrations, renal function and adverse effects frequently, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Tacrolimus?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Coadministration has been associated with higher tacrolimus concentrations. Elevated levels risk nephrotoxicity and neurotoxicity.
How serious is the interaction between Elbasvir / grazoprevir and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus whole blood concentrations, renal function and adverse effects frequently, and adjust the dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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