Drug interactions
Elbasvir / grazoprevir + Voriconazole
Severity: Moderate
Elbasvir / grazoprevir and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase elbasvir and grazoprevir levels. Higher grazoprevir exposure is associated with raised ALT, so liver toxicity is the main concern.
What this interaction means in plain words
Elbasvir / grazoprevir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4, which metabolizes both components.
What to do
Monitor liver enzymes during combined therapy and watch for signs of hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Voriconazole?
MediHelp rates the interaction as moderate. Elbasvir / grazoprevir and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase elbasvir and grazoprevir levels. Higher grazoprevir exposure is associated with raised ALT, so liver toxicity is the main concern.
How serious is the interaction between Elbasvir / grazoprevir and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during combined therapy and watch for signs of hepatotoxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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