Drug interactions
Eliglustat + Etoposide
Severity: Moderate
Eliglustat and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise etoposide exposure. This could increase myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Eliglustat and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Etoposide belongs to Oncology.
Why it happens
P-glycoprotein inhibition by eliglustat reduces etoposide efflux and clearance.
What to do
Monitor blood counts and etoposide toxicity, and reduce the etoposide dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporine + Etoposide Major
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Etoposide?
MediHelp rates the interaction as moderate. Eliglustat and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and may raise etoposide exposure. This could increase myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Eliglustat and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and etoposide toxicity, and reduce the etoposide dose if adverse effects appear.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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