Drug interactions
Eliglustat + Idarubicin
Severity: Moderate
Eliglustat and Idarubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein, and idarubicin is a P-gp substrate, so idarubicin exposure and toxicity could increase. Eliglustat may also affect cardiac conduction. Clinical data on the combination are lacking.
What this interaction means in plain words
Eliglustat and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Idarubicin belongs to Oncology.
Why it happens
Eliglustat inhibits P-glycoprotein efflux of idarubicin.
What to do
Monitor blood counts, mucositis and cardiac function. Consider reducing the idarubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Idarubicin?
MediHelp rates the interaction as moderate. Eliglustat and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein, and idarubicin is a P-gp substrate, so idarubicin exposure and toxicity could increase. Eliglustat may also affect cardiac conduction. Clinical data on the combination are lacking.
How serious is the interaction between Eliglustat and Idarubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, mucositis and cardiac function. Consider reducing the idarubicin dose if toxicity occurs.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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