Drug interactions
Eliglustat + Isoniazid
Severity: Moderate
Eliglustat and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4, and inhibition of these enzymes can increase exposure and raise the risk of PR, QRS, and QT prolongation. Isoniazid has weak inhibitory effects on both pathways, so the magnitude is uncertain.
What this interaction means in plain words
Eliglustat and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak inhibition of CYP3A4 and CYP2D6 metabolism of eliglustat.
What to do
Obtain an ECG and monitor for cardiac conduction effects, especially in CYP2D6 poor or intermediate metabolizers. Consider eliglustat dose reduction per labeling if other CYP inhibitors are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Isoniazid?
MediHelp rates the interaction as moderate. Eliglustat and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is metabolized by CYP2D6 and CYP3A4, and inhibition of these enzymes can increase exposure and raise the risk of PR, QRS, and QT prolongation. Isoniazid has weak inhibitory effects on both pathways, so the magnitude is uncertain.
How serious is the interaction between Eliglustat and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and monitor for cardiac conduction effects, especially in CYP2D6 poor or intermediate metabolizers. Consider eliglustat dose reduction per labeling if other CYP inhibitors are also used.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
