Drug interactions
Eliglustat + Lithium
Severity: Moderate
Eliglustat and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and lithium may add to QT effects. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Eliglustat and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac conduction and repolarization.
What to do
Obtain a baseline ECG and monitor the QTc during co-therapy. Correct electrolytes and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Lithium?
MediHelp rates the interaction as moderate. Eliglustat and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and lithium may add to QT effects. The combination may raise the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Eliglustat and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during co-therapy. Correct electrolytes and avoid other QT-prolonging drugs.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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