Drug interactions
Eliglustat + Metformin-sitagliptin
Severity: Minor
Eliglustat and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise sitagliptin concentrations. Sitagliptin has a wide therapeutic margin, so the effect is usually small.
What this interaction means in plain words
Eliglustat and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux of sitagliptin by eliglustat.
What to do
No routine dose change is needed. Monitor for adverse effects such as hypoglycemia or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Eliglustat and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and may raise sitagliptin concentrations. Sitagliptin has a wide therapeutic margin, so the effect is usually small.
How serious is the interaction between Eliglustat and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for adverse effects such as hypoglycemia or gastrointestinal upset.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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