Drug interactions
Eliglustat + Metronidazole
Severity: Moderate
Eliglustat and Metronidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4, and its exposure rises with CYP3A4 inhibitors, risking QT prolongation. Metronidazole is not an established moderate inhibitor and has its own QT liability, so the effect is uncertain.
What this interaction means in plain words
Eliglustat and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak CYP3A4 inhibition by metronidazole together with additive QT effects.
What to do
Obtain a baseline ECG and monitor for QT prolongation, especially in CYP2D6 poor or intermediate metabolizers. Consider an alternative antimicrobial if other QT risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Metronidazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Metronidazole?
MediHelp rates the interaction as moderate. Eliglustat and Metronidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is metabolized by CYP2D6 and CYP3A4, and its exposure rises with CYP3A4 inhibitors, risking QT prolongation. Metronidazole is not an established moderate inhibitor and has its own QT liability, so the effect is uncertain.
How serious is the interaction between Eliglustat and Metronidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor for QT prolongation, especially in CYP2D6 poor or intermediate metabolizers. Consider an alternative antimicrobial if other QT risks are present.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
