Drug interactions
Eliglustat + Octreotide
Severity: Moderate
Eliglustat and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmias, including torsades de pointes. Octreotide-related bradycardia may worsen this risk. Eliglustat exposure is also raised in patients with reduced CYP2D6 activity or taking CYP inhibitors, which increases the concern.
What this interaction means in plain words
Eliglustat and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Octreotide belongs to Endocrine.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and heart rate during therapy, and reassess the combination if QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Octreotide?
MediHelp rates the interaction as moderate. Eliglustat and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so using them together may add to the risk of ventricular arrhythmias, including torsades de pointes. Octreotide-related bradycardia may worsen this risk. Eliglustat exposure is also raised in patients with reduced CYP2D6 activity or taking CYP inhibitors, which increases the concern.
How serious is the interaction between Eliglustat and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and heart rate during therapy, and reassess the combination if QTc lengthens substantially.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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