Drug interactions
Eliglustat + Olanzapine
Severity: Moderate
Eliglustat and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and olanzapine may add a small QT effect. Combined use may raise arrhythmia risk in patients with heart disease or electrolyte disturbances.
What this interaction means in plain words
Eliglustat and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc, correcting electrolyte abnormalities. Avoid in patients with pre-existing cardiac disease or long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Olanzapine?
MediHelp rates the interaction as moderate. Eliglustat and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and olanzapine may add a small QT effect. Combined use may raise arrhythmia risk in patients with heart disease or electrolyte disturbances.
How serious is the interaction between Eliglustat and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, correcting electrolyte abnormalities. Avoid in patients with pre-existing cardiac disease or long QT.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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