Drug interactions
Eliglustat + Rifaximin
Severity: Minor
Eliglustat and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein, which may raise systemic exposure to rifaximin. Rifaximin is minimally absorbed, so the effect is usually small, but exposure could rise more in patients with hepatic impairment or a damaged gut barrier.
What this interaction means in plain words
Eliglustat and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Rifaximin belongs to Anti Bacterial.
Why it happens
Eliglustat inhibits intestinal P-glycoprotein efflux of rifaximin, increasing its absorption.
What to do
No routine dose change is needed. Monitor patients with severe hepatic impairment for rifaximin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Rifaximin?
MediHelp rates the interaction as minor. Eliglustat and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein, which may raise systemic exposure to rifaximin. Rifaximin is minimally absorbed, so the effect is usually small, but exposure could rise more in patients with hepatic impairment or a damaged gut barrier.
How serious is the interaction between Eliglustat and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor patients with severe hepatic impairment for rifaximin adverse effects.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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