Drug interactions
Eliglustat + Venlafaxine
Severity: Moderate
Eliglustat and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4 and can prolong the PR, QRS and QT intervals at high exposures. Venlafaxine is a weak CYP2D6 inhibitor and may have QT effects, so cardiac conduction effects could be additive.
What this interaction means in plain words
Eliglustat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Venlafaxine belongs to Central Nervous System.
Why it happens
Possible additive cardiac conduction effects and weak CYP2D6 inhibition raising eliglustat exposure.
What to do
Obtain a baseline ECG and monitor for palpitations or syncope. Avoid the combination in patients with pre-existing cardiac disease or long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Venlafaxine?
MediHelp rates the interaction as moderate. Eliglustat and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is metabolized by CYP2D6 and CYP3A4 and can prolong the PR, QRS and QT intervals at high exposures. Venlafaxine is a weak CYP2D6 inhibitor and may have QT effects, so cardiac conduction effects could be additive.
How serious is the interaction between Eliglustat and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor for palpitations or syncope. Avoid the combination in patients with pre-existing cardiac disease or long QT.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
