Drug interactions
Elranatamab + Phenytoin
Severity: Moderate
Elranatamab and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes and increase levels of narrow-therapeutic-index drugs such as phenytoin. This may produce phenytoin toxicity around step-up dosing and during CRS.
What this interaction means in plain words
Elranatamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 enzyme activity during cytokine release syndrome.
What to do
Monitor phenytoin levels and signs of toxicity during the step-up period and for up to 14 days after the first treatment dose, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Phenytoin?
MediHelp rates the interaction as moderate. Elranatamab and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes and increase levels of narrow-therapeutic-index drugs such as phenytoin. This may produce phenytoin toxicity around step-up dosing and during CRS.
How serious is the interaction between Elranatamab and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and signs of toxicity during the step-up period and for up to 14 days after the first treatment dose, adjusting the dose as needed.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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