Drug interactions
Carbamazepine + Elranatamab
Severity: Moderate
Carbamazepine and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after elranatamab can transiently suppress CYP enzymes and increase carbamazepine levels. This may cause toxicity such as dizziness, ataxia and confusion.
What this interaction means in plain words
Carbamazepine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity during cytokine release syndrome.
What to do
Monitor for carbamazepine toxicity and consider checking levels during step-up dosing and for about two weeks afterward. Adjust the dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
- Colchicine + Elranatamab Moderate
Frequently asked questions
Can I take Carbamazepine with Elranatamab?
MediHelp rates the interaction as moderate. Carbamazepine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after elranatamab can transiently suppress CYP enzymes and increase carbamazepine levels. This may cause toxicity such as dizziness, ataxia and confusion.
How serious is the interaction between Carbamazepine and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for carbamazepine toxicity and consider checking levels during step-up dosing and for about two weeks afterward. Adjust the dose if levels rise.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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