Drug interactions
Clomipramine + Elranatamab
Severity: Moderate
Clomipramine and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab causes cytokine release that can transiently suppress CYP enzymes, potentially raising exposure to substrates such as clomipramine. The effect is greatest during step-up dosing and around cytokine release syndrome episodes.
What this interaction means in plain words
Clomipramine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP enzyme activity (including CYP1A2) increases substrate exposure.
What to do
Monitor for clomipramine adverse effects, such as sedation, anticholinergic symptoms and arrhythmia, during the step-up period and any CRS. Reduce the dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
- Colchicine + Elranatamab Moderate
Frequently asked questions
Can I take Clomipramine with Elranatamab?
MediHelp rates the interaction as moderate. Clomipramine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab causes cytokine release that can transiently suppress CYP enzymes, potentially raising exposure to substrates such as clomipramine. The effect is greatest during step-up dosing and around cytokine release syndrome episodes.
How serious is the interaction between Clomipramine and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clomipramine adverse effects, such as sedation, anticholinergic symptoms and arrhythmia, during the step-up period and any CRS. Reduce the dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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