Drug interactions
Clozapine + Elranatamab
Severity: Moderate
Clozapine and Elranatamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab can trigger cytokine release syndrome, and the resulting inflammation suppresses hepatic CYP enzymes. Clozapine is mainly cleared by CYP1A2, so its levels may rise and cause sedation, seizures, hypotension or cardiac effects. The risk is greatest during step-up dosing and around any CRS episode.
What this interaction means in plain words
Clozapine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Elranatamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP1A2 reduces clozapine clearance.
What to do
Monitor for clozapine toxicity and consider checking clozapine levels during step-up dosing and for about two weeks after, especially during CRS. Reduce the clozapine dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Colchicine + Elranatamab Moderate
Frequently asked questions
Can I take Clozapine with Elranatamab?
MediHelp rates the interaction as moderate. Clozapine and Elranatamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab can trigger cytokine release syndrome, and the resulting inflammation suppresses hepatic CYP enzymes. Clozapine is mainly cleared by CYP1A2, so its levels may rise and cause sedation, seizures, hypotension or cardiac effects. The risk is greatest during step-up dosing and around any CRS episode.
How serious is the interaction between Clozapine and Elranatamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine toxicity and consider checking clozapine levels during step-up dosing and for about two weeks after, especially during CRS. Reduce the clozapine dose if signs of toxicity appear.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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