Drug interactions
Elranatamab + Theophylline
Severity: Moderate
Elranatamab and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes, including CYP1A2, which can increase theophylline exposure. This risk is greatest during step-up dosing and for some days after. A narrow therapeutic index makes toxicity a concern.
What this interaction means in plain words
Elranatamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Cytokine-mediated suppression of CYP1A2 and CYP3A4 reduces theophylline clearance.
What to do
Monitor theophylline concentrations and for toxicity during step-up dosing and any CRS, and reduce the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Theophylline?
MediHelp rates the interaction as moderate. Elranatamab and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes, including CYP1A2, which can increase theophylline exposure. This risk is greatest during step-up dosing and for some days after. A narrow therapeutic index makes toxicity a concern.
How serious is the interaction between Elranatamab and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline concentrations and for toxicity during step-up dosing and any CRS, and reduce the dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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