Drug interactions
Eltrombopag + Hydrochlorothiazide-valsartan
Severity: Minor
Eltrombopag and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1, a hepatic uptake transporter involved in valsartan clearance, and could modestly increase valsartan exposure. Clinically significant effects have not been well established.
What this interaction means in plain words
Eltrombopag and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Eltrombopag inhibition of OATP1B1 may reduce hepatic uptake of valsartan.
What to do
No dose adjustment is generally needed. Monitor blood pressure when eltrombopag is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Eltrombopag and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits OATP1B1, a hepatic uptake transporter involved in valsartan clearance, and could modestly increase valsartan exposure. Clinically significant effects have not been well established.
How serious is the interaction between Eltrombopag and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor blood pressure when eltrombopag is started or stopped.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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