Drug interactions
Eltrombopag + Meloxicam
Severity: Minor
Eltrombopag and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, which could in theory modestly raise exposure to drugs cleared by glucuronidation. Meloxicam is cleared mainly by CYP2C9 and CYP3A4, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Eltrombopag and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Meloxicam belongs to Musculoskeletal.
Why it happens
Theoretical UGT inhibition by eltrombopag; meloxicam is metabolized mainly by CYP2C9, so the relevance is unestablished.
What to do
No routine dose change is needed. Watch for NSAID adverse effects such as GI upset or fluid retention if meloxicam is used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Meloxicam?
MediHelp rates the interaction as minor. Eltrombopag and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, which could in theory modestly raise exposure to drugs cleared by glucuronidation. Meloxicam is cleared mainly by CYP2C9 and CYP3A4, so a clinically meaningful effect is unlikely.
How serious is the interaction between Eltrombopag and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for NSAID adverse effects such as GI upset or fluid retention if meloxicam is used long term.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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