Drug interactions
Eltrombopag + Metformin-repaglinide
Severity: Moderate
Eltrombopag and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits the OATP1B1 transporter and can raise repaglinide concentrations, which may enhance its glucose-lowering effect and cause hypoglycemia.
What this interaction means in plain words
Eltrombopag and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of repaglinide.
What to do
Monitor blood glucose closely when eltrombopag is started or stopped and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Eltrombopag and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits the OATP1B1 transporter and can raise repaglinide concentrations, which may enhance its glucose-lowering effect and cause hypoglycemia.
How serious is the interaction between Eltrombopag and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when eltrombopag is started or stopped and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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