Drug interactions
Eltrombopag + Miconazole
Severity: Minor
Eltrombopag and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is metabolized by several pathways including CYP1A2 and CYP2C8, with minor CYP2C9 involvement. Inhibition of CYP2C9 by miconazole is unlikely to change exposure meaningfully, especially after vaginal use. The interaction is mostly theoretical.
What this interaction means in plain words
Eltrombopag and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole may weakly inhibit CYP2C9-mediated eltrombopag metabolism, which is a minor pathway.
What to do
No dose adjustment is needed. Monitor platelet counts and liver tests as routinely recommended for eltrombopag.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Miconazole?
MediHelp rates the interaction as minor. Eltrombopag and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag is metabolized by several pathways including CYP1A2 and CYP2C8, with minor CYP2C9 involvement. Inhibition of CYP2C9 by miconazole is unlikely to change exposure meaningfully, especially after vaginal use. The interaction is mostly theoretical.
How serious is the interaction between Eltrombopag and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor platelet counts and liver tests as routinely recommended for eltrombopag.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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