Drug interactions
Eltrombopag + Morphine
Severity: Minor
Eltrombopag and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, which could in theory raise morphine exposure. The clinical significance has not been established.
What this interaction means in plain words
Eltrombopag and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
Theoretical inhibition of UGT-mediated morphine glucuronidation by eltrombopag.
What to do
No empirical dose change is needed; monitor for excessive sedation or respiratory depression when starting eltrombopag in opioid-treated patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Morphine?
MediHelp rates the interaction as minor. Eltrombopag and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, which could in theory raise morphine exposure. The clinical significance has not been established.
How serious is the interaction between Eltrombopag and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for excessive sedation or respiratory depression when starting eltrombopag in opioid-treated patients.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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