Drug interactions
Eltrombopag + Nateglinide
Severity: Moderate
Eltrombopag and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits the OATP1B1 transporter, which helps nateglinide enter hepatocytes, so nateglinide exposure may rise. This can increase glucose lowering and the risk of hypoglycemia. The effect of nateglinide on eltrombopag is not clinically established.
What this interaction means in plain words
Eltrombopag and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Nateglinide belongs to Endocrine.
Why it happens
Eltrombopag inhibits OATP1B1, reducing hepatic uptake and clearance of nateglinide.
What to do
Monitor blood glucose when eltrombopag is started and lower the nateglinide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Nateglinide?
MediHelp rates the interaction as moderate. Eltrombopag and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits the OATP1B1 transporter, which helps nateglinide enter hepatocytes, so nateglinide exposure may rise. This can increase glucose lowering and the risk of hypoglycemia. The effect of nateglinide on eltrombopag is not clinically established.
How serious is the interaction between Eltrombopag and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when eltrombopag is started and lower the nateglinide dose if hypoglycemia develops.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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